Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 5/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090279 | 1.00 | LMNA (0.40) | LMNACYP1A2CYP3A4MAOAJAK2 | |
| SCHEMBL6091331 | 0.91 | CA12 (0.39) | LMNAJAK2JAK3PARP1KDR | |
| SCHEMBL6091332 | 0.91 | CA12 (0.39) | LMNAJAK2JAK3PARP1KDR | |
| SCHEMBL6090324 | 0.90 | MAPT (0.38) | KMT2AKDRGABRA1GABRB2NPC1 | |
| SCHEMBL6090321 | 0.90 | MAPT (0.38) | KMT2AKDRGABRA1GABRB2NPC1 | |
| SCHEMBL6090037 | 0.83 | PDPK1 (0.39) | KMT2AKDRNPC1RAB9AMEN1 | |
| SCHEMBL6089552 | 0.81 | JAK2 (0.40) | LMNACYP1A2CYP3A4MAOAJAK2 | |
| SCHEMBL6089558 | 0.81 | JAK2 (0.40) | LMNACYP1A2CYP3A4MAOAJAK2 | |
| SCHEMBL6088593 | 0.79 | GFER (0.32) | — | |
| SCHEMBL6091001 | 0.79 | GFER (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |