Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.70 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.56 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.56 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 5/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NSD2 | O96028 | 1/20 | 0.51 |
| ▸ | AS3MT | Q9HBK9 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | KIF20A | O95235 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5857843 | 0.92 | IMPDH2 (0.81) | IMPDH2LTA4HPLA2G2AMAOBTRPM8 | |
| SCHEMBL6086627 | 0.87 | PFKFB2 (0.59) | IMPDH2PFKFB2PFKFB1PFKFB3LTA4H | |
| SCHEMBL27708665 | 0.82 | IMPDH2 (1.00) | IMPDH2LTA4HPLA2G2AMAOBTRPM8 | |
| SCHEMBL6087313 | 0.80 | PFKFB2 (0.61) | IMPDH2PFKFB2PFKFB1PFKFB3TRPM8 | |
| SCHEMBL1657036 | 0.79 | MAOB (0.82) | IMPDH2MAOBMAPT | |
| SCHEMBL5858420 | 0.76 | AS3MT (0.86) | IMPDH2PFKFB2PFKFB1PFKFB3LTA4H | |
| SCHEMBL6087198 | 0.76 | LTA4H (0.55) | LTA4HPLA2G2ATRPM8KDM4EMAPT | |
| SCHEMBL1336627 | 0.76 | MAOB (0.62) | IMPDH2MAOBKDM4EMAPTNSD2 | |
| SCHEMBL273476 | 0.75 | TRPM8 (0.67) | IMPDH2LTA4HPLA2G2ATRPM8KDM4E | |
| SCHEMBL187805 | 0.75 | IMPDH2 (0.65) | IMPDH2MAOBMAPTSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125906-B2 | Indole derivatives having anti-angiogenetic activity | ASTRAZENECA AB (SE) | 2006-10-24 | — | — | US | disclosed |
| US-20050159474-A1 | Angiogenesis inhibitors for cardiovascular disorders, neovascularization | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | US | disclosed |
| EP-1515716-A2 | INDOLE DERIVATIVES HAVING ANTI-ANGIOGENETIC ACTIVITY | Astrazeneca AB (SE) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003082271-A2 | INDOLE DERIVATIVES HAVING ANTI-ANGIOGENETIC ACTIVITY | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159474-A1 | Angiogenesis inhibitors for cardiovascular disorders, neovascularization | FLT1, FLT4, VEGFA | IMPDH2 3719/4885PFKFB2 1285/4885PFKFB1 799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.