Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090533 | 1.00 | ALOX5 (0.46) | ALOX5ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL6090981 | 0.94 | ALOX5 (0.46) | ALOX5ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL6090979 | 0.94 | ALOX5 (0.46) | ALOX5ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL6089845 | 0.92 | HTR6 (0.41) | ALOX5ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL6089849 | 0.92 | HTR6 (0.41) | ALOX5ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL6089001 | 0.81 | ABL1 (0.45) | ALOX5ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL6089004 | 0.81 | ABL1 (0.45) | ALOX5ALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL6091976 | 0.80 | JAK2 (0.38) | ALOX5KDM4EMAPTMEN1KMT2A | |
| SCHEMBL6091985 | 0.80 | JAK2 (0.38) | ALOX5KDM4EMAPTMEN1KMT2A | |
| SCHEMBL7496610 | 0.80 | PIK3CA (0.41) | ALDH1A1KDM4EMAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |