Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 8/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.48 |
| ▸ | TLK2 | Q86UE8 | 6/20 | 0.48 |
| ▸ | KDR | P35968 | 5/20 | 0.48 |
| ▸ | RET | P07949 | 4/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6091687 | 1.00 | ALDH1A1 (0.51) | ALDH1A1PDPK1PDGFRBTLK2KDR | |
| SCHEMBL6091834 | 0.77 | PARP1 (0.36) | — | |
| SCHEMBL6091915 | 0.77 | PDPK1 (0.54) | ALDH1A1PDPK1PDGFRBTLK2KDR | |
| SCHEMBL6091912 | 0.77 | PDPK1 (0.54) | ALDH1A1PDPK1PDGFRBTLK2KDR | |
| SCHEMBL6090843 | 0.76 | MAP4K1 (0.36) | PDPK1KDR | |
| SCHEMBL6090841 | 0.76 | MAP4K1 (0.36) | PDPK1KDR | |
| SCHEMBL6092658 | 0.76 | SIRT1 (0.51) | — | |
| SCHEMBL6092653 | 0.76 | SIRT1 (0.51) | — | |
| SCHEMBL6089556 | 0.76 | ALDH1A1 (0.51) | ALDH1A1PDPK1PDGFRBTLK2KDR | |
| SCHEMBL6089559 | 0.76 | ALDH1A1 (0.51) | ALDH1A1PDPK1PDGFRBTLK2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |