Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090841 | 1.00 | MAP4K1 (0.36) | MAP4K1KDRPDPK1BACE1 | |
| SCHEMBL6091683 | 0.76 | ALDH1A1 (0.51) | KDRPDPK1 | |
| SCHEMBL6091997 | 0.74 | MAP4K1 (0.33) | MAP4K1 | |
| SCHEMBL6092000 | 0.74 | MAP4K1 (0.33) | MAP4K1 | |
| SCHEMBL6091834 | 0.73 | PARP1 (0.36) | — | |
| SCHEMBL6087571 | 0.72 | MAP4K1 (0.34) | MAP4K1 | |
| SCHEMBL6091586 | 0.72 | TLK2 (0.34) | MAP4K1 | |
| SCHEMBL6091588 | 0.72 | TLK2 (0.34) | MAP4K1 | |
| SCHEMBL6091887 | 0.72 | KDR (0.58) | KDR | |
| SCHEMBL6090338 | 0.71 | MAP4K1 (0.32) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |