Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2262431 | 0.88 | CHRM4 (0.65) | ALDH1A1TSHRCYP2D6CHRM4POLB | |
| SCHEMBL7486412 | 0.81 | ALDH1A1 (0.58) | ALDH1A1ACKR3POLB | |
| SCHEMBL5368002 | 0.79 | GAA (0.69) | ALDH1A1MAPTHTTHRH3 | |
| SCHEMBL30924045 | 0.78 | ACKR3 (0.62) | ACKR3HTT | |
| SCHEMBL2073212 | 0.77 | DRD2 (0.60) | ALDH1A1MAPTHTTHRH3 | |
| SCHEMBL14124454 | 0.76 | ACHE (0.63) | ALDH1A1HTT | |
| SCHEMBL21820693 | 0.76 | TEAD1 (0.58) | ALDH1A1MAPTHTT | |
| SCHEMBL19554726 | 0.76 | KDM4E (0.72) | ALDH1A1TSHRCHRM4 | |
| SCHEMBL6705571 | 0.75 | ALDH1A1 (0.61) | ALDH1A1MAPTTSHRHTTCYP2D6 | |
| SCHEMBL6093929 | 0.75 | DRD2 (0.54) | ALDH1A1MAPTHTTCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125895-B1 | Cyclic amine derivatives and their uses | BRISTOL-MYERS SQUIBB PHARMA RESEARCH LABS, INC. (US) | 2006-10-24 | — | — | US | disclosed |
| EP-1181278-B1 | CYCLIC AMINE DERIVATIVES AND THEIR USES | BRISTOL MYERS SQUIBB PHARMA RE (US) | 2004-09-29 | — | — | EP | disclosed |