Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TNFRSF1A | P19438 | 8/20 | 0.45 |
| ▸ | GLP1R | P43220 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092548 | 0.85 | KDM4E (0.50) | HDAC1HDAC2HDAC3KMT2AL3MBTL1 | |
| SCHEMBL6091940 | 0.84 | TNFRSF1A (0.52) | HDAC1HDAC2KMT2AL3MBTL1KDM4E | |
| SCHEMBL6092780 | 0.84 | TNFRSF1A (0.50) | HDAC1HDAC2KMT2AL3MBTL1KDM4E | |
| SCHEMBL6091730 | 0.84 | MEN1 (0.45) | HDAC1HDAC2HDAC3KMT2AL3MBTL1 | |
| SCHEMBL6091629 | 0.83 | TNFRSF1A (0.49) | HDAC1HDAC2KMT2AL3MBTL1KDM4E | |
| SCHEMBL6091875 | 0.83 | TNFRSF1A (0.53) | HDAC1HDAC2HDAC3KMT2AL3MBTL1 | |
| SCHEMBL6091870 | 0.83 | TNFRSF1A (0.52) | HDAC1HDAC2HDAC3KMT2AL3MBTL1 | |
| SCHEMBL6092872 | 0.82 | TNFRSF1A (0.46) | HDAC1HDAC2KMT2AL3MBTL1KDM4E | |
| SCHEMBL6091933 | 0.82 | ALDH1A1 (0.49) | HDAC1HDAC2HDAC3KMT2AL3MBTL1 | |
| SCHEMBL6091397 | 0.82 | KDM4E (0.49) | HDAC1HDAC2HDAC3KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060063828-A1 | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof | ATHEROGENICS, INC. | 2006-03-23 | — | — | US | disclosed |
| WO-2006004903-A2 | 1,2-BIS-(SUBSTITUTED-PHENYL)-2-PROPEN-1-ONES AND PHARMACEUTICAL COMPOSITIONS THEREOF | ATHEROGENICS, INC. (US) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063828-A1 | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof | ABCB11, CEL, CYP46A1 | HDAC1 1097/4885HDAC2 651/4885HDAC3 735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.