Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.44 |
| ▸ | DHFR | P00374 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092911 | 1.00 | SIRT1 (0.46) | SIRT1SIRT5MAPK14KMT2ADHFR | |
| SCHEMBL6090831 | 0.91 | MAPK14 (0.49) | SIRT1SIRT5MAPK14KMT2ADHFR | |
| SCHEMBL6090641 | 0.90 | MEN1 (0.45) | MAPK14KMT2AMEN1POLBKDR | |
| SCHEMBL6090637 | 0.90 | MEN1 (0.45) | MAPK14KMT2AMEN1POLBKDR | |
| SCHEMBL6090622 | 0.87 | GSK3B (0.44) | KMT2AMEN1KDRMAPT | |
| SCHEMBL6090619 | 0.87 | GSK3B (0.44) | KMT2AMEN1KDRMAPT | |
| SCHEMBL6090511 | 0.84 | KMT2A (0.48) | KMT2ADHFRMEN1POLBKDR | |
| SCHEMBL6090516 | 0.84 | KMT2A (0.48) | KMT2ADHFRMEN1POLBKDR | |
| SCHEMBL6090331 | 0.81 | KMT2A (0.45) | SIRT1SIRT5KMT2ADHFRMEN1 | |
| SCHEMBL6090339 | 0.81 | KMT2A (0.45) | SIRT1SIRT5KMT2ADHFRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | claimed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | claimed |
| US-7060822-B1 | 2-pyrazolin-5-ones | ABBOTT GMBH & CO. KG (DE) | 2006-06-13 | — | — | US | disclosed |
| EP-1218373-A2 | 2-PYRAZOLIN-5-ONES AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001009121-A2 | 2-PYRAZOLIN-5-ONES_AS TYROSINE KINASE INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-02-08 | — | — | WO | disclosed |