Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 7/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6091297 | 0.90 | KCNH2 (0.47) | KDM4EESR1ESR2MCHR1KCNH2 | |
| SCHEMBL6092086 | 0.86 | SMN1; SMN2 (0.46) | MEN1GAAKMT2ANPC1RAB9A | |
| SCHEMBL6092548 | 0.82 | KDM4E (0.50) | KDM4EMEN1KMT2AATMNPC1 | |
| SCHEMBL6110229 | 0.81 | LTA4H (0.42) | KDM4EMEN1KMT2AATMNPC1 | |
| SCHEMBL6092689 | 0.78 | MAPT (0.45) | KDM4EMEN1KMT2AATMNPC1 | |
| SCHEMBL6094350 | 0.77 | TNFRSF1A (0.45) | KDM4EMEN1GAAKMT2ANPC1 | |
| SCHEMBL6092917 | 0.76 | SMN1; SMN2 (0.43) | MEN1GAAKMT2ANPC1RAB9A | |
| SCHEMBL6094179 | 0.74 | HRH3 (0.56) | KDM4EESR1ESR2MCHR1KCNH2 | |
| SCHEMBL6092780 | 0.73 | TNFRSF1A (0.50) | KDM4EMEN1KMT2A | |
| SCHEMBL6091940 | 0.73 | TNFRSF1A (0.52) | KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060063828-A1 | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof | ATHEROGENICS, INC. | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063828-A1 | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof | ABCB11, CEL, CYP46A1 | KDM4E 1931/4885ESR1 3626/4885ESR2 2668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.