Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1819112 | 0.77 | KCNH2 (0.59) | KCNH2TDP1L3MBTL1PDPK1HRH1 | |
| SCHEMBL4800682 | 0.75 | L3MBTL1 (0.47) | TDP1L3MBTL1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL9762812 | 0.74 | TLR8 (0.43) | KCNH2TLR7 | |
| SCHEMBL899234 | 0.74 | KCNH2 (0.55) | KCNH2TDP1L3MBTL1PDPK1KDM4E | |
| SCHEMBL11561943 | 0.74 | KCNH2 (0.55) | KCNH2TDP1L3MBTL1PDPK1KDM4E | |
| SCHEMBL2496375 | 0.73 | TLR8 (0.43) | TLR7 | |
| SCHEMBL17053275 | 0.73 | KCNH2 (0.58) | KCNH2TDP1L3MBTL1LMNAKDM4E | |
| SCHEMBL27977748 | 0.73 | KCNH2 (0.58) | KCNH2TDP1L3MBTL1LMNAKDM4E | |
| SCHEMBL22298878 | 0.73 | KCNH2 (0.58) | KCNH2TDP1L3MBTL1LMNAKDM4E | |
| SCHEMBL3248683 | 0.73 | KCNH2 (0.53) | KCNH2PDPK1KDM4ESMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0052959-B1 | PRODUCTION OF PURINE DERIVATIVES AND INTERMEDIATES THEREFOR | Takeda Chemical Industries, Ltd. (JP) | 1986-01-29 | — | — | EP | claimed |
| EP-0052959-A1 | Production of purine derivatives and intermediates therefor | Takeda Chemical Industries, Ltd. (JP) | 1982-06-02 | — | — | EP | claimed |
| JP-58032867-A | — | — | None | — | — | JP | disclosed |
| US-20120130058-A1 | REDUCTION OF 5-(ARYL-DIAZENYL)-4,6-DIHALO-PYRIMIDINE | QUITTMANN WILHELM (CH) | 2012-05-24 | — | — | US | disclosed |
| US-8114996-B2 | Reduction of 5-(aryl-diazenyl)-4,6-dihalo-pyrimidine | LONZA AG (CH) | 2012-02-14 | — | — | US | disclosed |
| US-20110178298-A1 | REDUCTION OF 5-(ARYL-DIAZENYL)-4,6-DIHALO-PYRIMIDINE | LONZA AG (CH) | 2011-07-21 | — | — | US | disclosed |
| US-20100302487-A1 | PHASE COMPENSATION FILM | DOW GLOBAL TECHNOLOGIES LLC | 2010-12-02 | — | — | US | disclosed |
| US-20100294989-A1 | SMALL SCALE FUNCTIONAL MATERIALS | DOW GLOBAL TECHNOLOGIES LLC | 2010-11-25 | — | — | US | disclosed |
| EP-2231760-A1 | SMALL SCALE FUNCTIONAL MATERIALS | Dow Global Technologies Inc. (US) | 2010-09-29 | — | — | EP | disclosed |
| EP-2225604-A1 | PHASE COMPENSATION FILM COMPRISING POLYMER NANOPARTICLES IMBIBED WITH LIQUID CRYSTAL MATERIAL | Dow Global Technologies Inc. (US) | 2010-09-08 | — | — | EP | disclosed |
| EP-1987012-B1 | REDUCTION OF 5-(ARYL-DIAZENYL)-4,6-DIHALO-PYRIMIDINE | LONZA AG (CH) | 2010-05-05 | — | — | EP | disclosed |
| US-5516905-A | ENZYME INHIBITORS OF DNA POLYMERASE FOR BACTERICIDES | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1996-05-14 | — | — | US | disclosed |
| WO-1996006614-A1 | NOVEL ANTIBIOTIC COMPOUNDS AND METHODS TO TREAT GRAM-POSITIVE BACTERIAL AND MYCOPLASMAL INFECTIONS | UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER (US) | 1996-03-07 | — | — | WO | disclosed |
| EP-0052959-B1 | PRODUCTION OF PURINE DERIVATIVES AND INTERMEDIATES THEREFOR | Takeda Chemical Industries, Ltd. (JP) | 1986-01-29 | — | — | EP | disclosed |
| EP-0101273-A2 | Production of biological products using resting cells | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 1984-02-22 | — | — | EP | disclosed |
| US-4423219-A | 6-/2-CHLORO-6-FLUOROBENZYL/AMINO-4-METHYLAMINO-5 -PHENYLAZOPYRIMIDINE, ANTIPROTOZOA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1983-12-27 | — | — | US | disclosed |
| US-4423219-A | 6-/2-CHLORO-6-FLUOROBENZYL/AMINO-4-METHYLAMINO-5 -PHENYLAZOPYRIMIDINE, ANTIPROTOZOA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1983-12-27 | — | — | US | disclosed |
| JP-S5832867-A | NOVEL ARYLAZOPYRIMIDINE COMPOUND | TAKEDA CHEM IND LTD | 1983-02-25 | — | — | JP | disclosed |
| EP-0052959-A1 | Production of purine derivatives and intermediates therefor | Takeda Chemical Industries, Ltd. (JP) | 1982-06-02 | — | — | EP | disclosed |
| EP-0052959-A1 | Production of purine derivatives and intermediates therefor | Takeda Chemical Industries, Ltd. (JP) | 1982-06-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178298-A1 | REDUCTION OF 5-(ARYL-DIAZENYL)-4,6-DIHALO-PYRIMIDINE | PDXK, KHK, GCK | KCNH2 234/4885TDP1 2764/4885L3MBTL1 2993/4885 |
| US-20120130058-A1 | REDUCTION OF 5-(ARYL-DIAZENYL)-4,6-DIHALO-PYRIMIDINE | PDXK, KHK, GCK | KCNH2 234/4885TDP1 2764/4885L3MBTL1 2993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.