Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.52 |
| ▸ | TNFRSF1A | P19438 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6094048 | 0.84 | ERN1 (0.50) | ERN1TNFRSF1ASMN1; SMN2MAPTRAB9A | |
| SCHEMBL6092784 | 0.83 | ERN1 (0.50) | ERN1TNFRSF1ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL6093221 | 0.81 | ERN1 (0.48) | ERN1TNFRSF1ASMN1; SMN2MAPTRAB9A | |
| SCHEMBL6095253 | 0.79 | ERN1 (0.52) | ERN1TNFRSF1ASMN1; SMN2MAPTHPGD | |
| SCHEMBL6091842 | 0.79 | ERN1 (0.47) | ERN1TNFRSF1ASMN1; SMN2MAPTRAB9A | |
| SCHEMBL6092824 | 0.77 | TNFRSF1A (0.51) | ERN1TNFRSF1ARAB9AMEN1ALDH1A1 | |
| SCHEMBL6093616 | 0.77 | ERN1 (0.44) | ERN1TNFRSF1AMAPTHPGDMEN1 | |
| SCHEMBL6093475 | 0.73 | ERN1 (0.45) | ERN1TNFRSF1ASMN1; SMN2MAPTRAB9A | |
| SCHEMBL6095256 | 0.71 | TNFRSF1A (0.47) | ERN1TNFRSF1AMEN1ALDH1A1KMT2A | |
| SCHEMBL27601843 | 0.70 | ERN1 (0.55) | ERN1TNFRSF1ASMN1; SMN2MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060063828-A1 | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof | ATHEROGENICS, INC. | 2006-03-23 | — | — | US | claimed |
| US-20060063828-A1 | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof | ATHEROGENICS, INC. | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063828-A1 | 1,2-Bis-(substituted-phenyl)-2-propen-1-ones and pharmaceutical compositions thereof | ABCB11, CEL, CYP46A1 | ERN1 2367/4885TNFRSF1A 4880/4885SMN1; SMN2 2250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.