Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 10/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | GMNN | O75496 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | APEX1 | P27695 | 4/20 | 0.37 |
| ▸ | RECQL | P46063 | 4/20 | 0.37 |
| ▸ | BLM | P54132 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3391710 | 0.80 | MAPT (0.59) | MAPTNPSR1KDM4ENPC1HTT | |
| SCHEMBL7256323 | 0.78 | ACHE (0.45) | MAPTNPSR1KDM4ENPC1HTT | |
| SCHEMBL28383828 | 0.77 | ATM (0.38) | MAPTNPSR1KDM4ENPC1HTT | |
| SCHEMBL10901434 | 0.77 | MAPT (0.56) | MAPTNPSR1KDM4ENPC1HTT | |
| Iodide SCHEMBL10549487 | 0.77 | ACHE (0.44) | MAPTNPSR1KDM4EHTTPRKCA | |
| SCHEMBL10999954 | 0.74 | MAPT (0.53) | MAPTNPSR1KDM4ENPC1HTT | |
| SCHEMBL7761625 | 0.74 | MAPT (0.53) | MAPTNPSR1KDM4ENPC1HTT | |
| Sulfuric Acid SCHEMBL11673617 | 0.74 | ACHE (0.38) | MAPTNPSR1KDM4ENPC1HTT | |
| SCHEMBL8725225 | 0.73 | ACHE (0.51) | KDM4EHTTSMN1; SMN2ACHE | |
| SCHEMBL5157864 | 0.72 | MAPT (1.00) | MAPTNPSR1KDM4ENPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |