Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8295958 | 0.84 | ALDH1A1 (0.64) | KEAP1ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL6096614 | 0.81 | MAPK14 (0.56) | ALDH1A1MEN1KMT2AUSP2TSHR | |
| SCHEMBL8296024 | 0.81 | MAPK1 (0.65) | ALDH1A1MEN1KMT2AUSP2TSHR | |
| SCHEMBL6096895 | 0.80 | ALDH1A1 (0.47) | KEAP1ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL8291050 | 0.80 | KEAP1 (0.54) | KEAP1ALDH1A1KMT2ATSHRPDPK1 | |
| SCHEMBL6094784 | 0.79 | HTR2A (0.45) | KEAP1MEN1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL6094782 | 0.79 | HCRTR1 (0.41) | KEAP1ALDH1A1MEN1KMT2AHCRTR1 | |
| SCHEMBL9432576 | 0.79 | MAPT (0.53) | KEAP1ALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL8291046 | 0.77 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2AHCRTR1HCRTR2 | |
| SCHEMBL2214668 | 0.77 | KEAP1 (0.57) | KEAP1ALDH1A1TSHRHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084143-B2 | N-(indolecarbonyl) piperazine derivatives | MERCK PATENT GMBH (DE) | 2006-08-01 | — | — | US | claimed |
| US-6838461-B1 | N-(indolcarbonyl-)piperazine derivatives | MERCK PATENT GMBH (DE) | 2005-01-04 | — | — | US | claimed |
| US-20050096330-A1 | N-(indolecarbonyl) piperazine derivatives | BOETTCHER HENNING (DE) | 2005-05-05 | — | — | US | disclosed |
| CN-1364157-A | N-(indolcarbonyl) piperazin derivatives | MERCK PATENT GMBH (DE) | 2002-08-14 | — | — | CN | disclosed |
| EP-1198453-A2 | N-(INDOLCARBONYL-)PIPERAZIN DERIVATIVES | MERCK PATENT GmbH (DE) | 2002-04-24 | — | — | EP | disclosed |
| WO-2001007435-A2 | N-(INDOLCARBONYL-)PIPERAZIN DERIVATIVES ALS 5-HT2A-RECEPTOR LIGANDS | MERCK PATENT GMBH (DE) | 2001-02-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096330-A1 | N-(indolecarbonyl) piperazine derivatives | HTR2A, HTR2B, HTR2C | KEAP1 2710/4885ALDH1A1 2239/4885MEN1 1162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.