Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPRA | P18433 | 1/20 | 0.41 |
| ▸ | PTPRB | P23467 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1666735 | 1.00 | SLC6A2 (0.50) | SLC6A2TAAR1SMN1; SMN2HIF1AMMP1 | |
| SCHEMBL971950 | 0.84 | SLC6A2 (0.52) | SLC6A2TAAR1SMN1; SMN2HIF1AMMP1 | |
| SCHEMBL10661517 | 0.82 | SMN1; SMN2 (0.48) | SLC6A2TAAR1SMN1; SMN2HIF1AMMP1 | |
| Phentermine SCHEMBL28338903 | 0.78 | SLC6A2 (0.76) | SLC6A2TAAR1SMN1; SMN2HIF1AMMP1 | |
| SCHEMBL5465236 | 0.78 | SLC6A2 (0.48) | SLC6A2TAAR1SMN1; SMN2HIF1AMMP1 | |
| SCHEMBL4127162 | 0.77 | PTPN2 (0.40) | SLC6A2TAAR1SMN1; SMN2HIF1AMMP1 | |
| Sulfuric Acid SCHEMBL5465234 | 0.77 | SLC6A2 (0.55) | SLC6A2TAAR1SMN1; SMN2HIF1AMMP1 | |
| Phentermine SCHEMBL28815884 | 0.77 | SLC6A2 (0.73) | SLC6A2TAAR1SMN1; SMN2HIF1AMMP1 | |
| SCHEMBL10397637 | 0.75 | PTPN2 (0.40) | SLC6A2TAAR1SMN1; SMN2HIF1AMMP1 | |
| Ammonia Solution, Strong SCHEMBL340103 | 0.74 | SLC6A2 (0.52) | SLC6A2TAAR1SMN1; SMN2HIF1ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7078565-B2 | Benzamide derivatives as antagonists of orexin receptors | SMITHKLINE BEECHAM PLC (GB) | 2006-07-18 | — | — | US | disclosed |
| US-20050020584-A1 | Benzamide derivatives as antagonists of orexin receptors | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020584-A1 | Benzamide derivatives as antagonists of orexin receptors | HCRTR2, HCRTR1, OXTR | SLC6A2 630/4885TAAR1 154/4885SMN1; SMN2 3217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.