Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 11/20 | 0.40 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 3/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6092227 | 0.91 | HTR2C (0.44) | HTR2CHTR2BCLK2DYRK1A | |
| SCHEMBL8258169 | 0.89 | HTR2C (0.37) | HTR2CHTR2AHTR2BBUB1NAMPT | |
| SCHEMBL6092499 | 0.87 | HTR2C (0.53) | HTR2CHTR2AHTR2BBUB1 | |
| SCHEMBL8251851 | 0.86 | HTR2C (0.43) | HTR2CBUB1CLK2DYRK1A | |
| SCHEMBL6091806 | 0.83 | HTR2C (0.53) | HTR2CHTR2AHTR2BBUB1 | |
| SCHEMBL8258291 | 0.82 | HTR2C (0.46) | HTR2CHTR2B | |
| SCHEMBL8584124 | 0.81 | KMT2A (0.45) | HTR2CMAPTSMN1; SMN2 | |
| SCHEMBL6093576 | 0.81 | HTR2C (0.38) | HTR2CBUB1CLK2DYRK1AMAPT | |
| SCHEMBL6094099 | 0.80 | HTR2C (0.39) | HTR2CBUB1CLK2DYRK1ACD38 | |
| SCHEMBL7384705 | 0.79 | BUB1 (0.43) | BUB1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109351-B1 | Fused pyrrolecarboxamides; GABA brain receptor ligands | NEUROGEN CORPORATION (US) | 2006-09-19 | — | — | US | disclosed |
| US-20050014939-A1 | Fused pyrrolecarboxamides: GABA brain receptor ligands | NEUROGEN CORPORATION | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014939-A1 | Fused pyrrolecarboxamides: GABA brain receptor ligands | GABRB2, GABRB1, GABRB3 | HTR2C 227/4885NOX1 4507/4885HTR2A 206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.