Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 10/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12440542 | 0.83 | GAA (0.44) | HTR7HTR1AHTR2AITGB1ITGA4 | |
| SCHEMBL1103915 | 0.72 | GAA (0.52) | HTR7HTR1AHTR2AGAAMCOLN3 | |
| SCHEMBL3392545 | 0.71 | HTR7 (0.46) | HTR7HTR1AHTR2ANPC1RAB9A | |
| SCHEMBL6097493 | 0.70 | HTR7 (0.55) | HTR7HTR1AHTR2AGAAMCOLN3 | |
| SCHEMBL7541463 | 0.69 | GAA (0.63) | ITGB1ITGA4NPC1RAB9AGAA | |
| SCHEMBL6097398 | 0.68 | HTR7 (0.63) | HTR7HTR1AHTR2AITGB1ITGA4 | |
| SCHEMBL6099295 | 0.67 | HTR7 (0.62) | HTR7HTR1AHTR2AITGB1ITGA4 | |
| 1,4-Butanediol SCHEMBL28575010 | 0.65 | TSHR (0.73) | TSHRSMN1; SMN2 | |
| 1,3-Propanediol SCHEMBL16044212 | 0.65 | TSHR (0.73) | TSHRSMN1; SMN2 | |
| SCHEMBL8394591 | 0.65 | GAA (0.52) | HTR7HTR1AHTR2AGAAMCOLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | HTR7 1/4885HTR1A 3/4885HTR2A 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.