Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 13/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6097607 | 0.82 | TSHR (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6094391 | 0.82 | TSHR (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6094393 | 0.82 | TSHR (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6098151 | 0.75 | KMT2A (0.52) | KMT2AFBP1NLRP3ALDH1A1 | |
| SCHEMBL751112 | 0.73 | KMT2A (0.50) | KMT2AFBP1NLRP3ALDH1A1 | |
| SCHEMBL27596168 | 0.72 | KMT2A (0.46) | KMT2AFBP1NLRP3ALDH1A1 | |
| SCHEMBL10765775 | 0.72 | KMT2A (0.49) | KMT2AFBP1NLRP3ALDH1A1 | |
| SCHEMBL10767304 | 0.72 | KMT2A (0.43) | KMT2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8257058 | 0.70 | KMT2A (0.51) | KMT2AFBP1HCRTR2ALDH1A1 | |
| SCHEMBL10764574 | 0.70 | KMT2A (0.44) | KMT2APSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | KMT2A 2168/4885PSEN1 1955/4885PSEN2 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.