Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6097798 | 0.86 | LMNA (0.30) | LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6097678 | 0.86 | GAA (0.33) | GAARAD52 | |
| SCHEMBL6600080 | 0.85 | LMNA (0.31) | LMNASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6097647 | 0.76 | RAD52 (0.34) | GAARAD52THRB | |
| Hydrochloric Acid SCHEMBL6097774 | 0.75 | GAA (0.34) | GAARAD52THRB | |
| Hydrochloric Acid SCHEMBL6095670 | 0.73 | GAA (0.32) | GAARAD52 | |
| Hydrochloric Acid SCHEMBL6096827 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL6098054 | 0.71 | — | — | |
| SCHEMBL6385931 | 0.70 | RAD52 (0.35) | GAARAD52THRB | |
| SCHEMBL3245667 | 0.70 | RAD52 (0.40) | GAARAD52THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132543-B2 | Para-phenylenediamine derivatives containing a disubstituted pyrrolidinyl group bearing a cationic radical, and use of the same for dyeing keratin fibers | L'OREAL S.A. (FR) | 2006-11-07 | — | — | US | disclosed |