Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6095430 | 0.95 | ITGB3 (0.41) | ALDH1A1KDM4EITGB3ITGB1ITGAV | |
| SCHEMBL6096971 | 0.95 | ITGB3 (0.39) | ALDH1A1KDM4EITGB3ITGB1ITGAV | |
| SCHEMBL6096241 | 0.94 | ALDH1A1 (0.40) | ALDH1A1KDM4EITGB3POLBCYP2D6 | |
| SCHEMBL6096581 | 0.89 | ALDH1A1 (0.39) | ALDH1A1KDM4EITGB3ITGB1ITGAV | |
| SCHEMBL6098578 | 0.88 | ITGA5 (0.39) | ALDH1A1KDM4EITGB3ITGAVITGB6 | |
| SCHEMBL6096530 | 0.87 | ITGB3 (0.43) | ALDH1A1KDM4EITGB3ITGB1ITGAV | |
| SCHEMBL6098962 | 0.86 | ALDH1A1 (0.36) | ALDH1A1ITGB3ITGAVCYP1A2POLB | |
| SCHEMBL6096925 | 0.85 | ITGB3 (0.38) | ALDH1A1KDM4EITGB3ITGB1ITGAV | |
| SCHEMBL6097109 | 0.82 | ITGB3 (0.42) | ALDH1A1ITGB3ITGB1ITGAVITGB6 | |
| SCHEMBL6095422 | 0.82 | ITGB3 (0.47) | ALDH1A1ITGB3ITGB1ITGAVITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224948-A1 | Novel substituted benzoxazines as integrin antagonists | PHARMACIA & UPJOHN S.P.A. (IT) | 2004-11-11 | — | — | US | claimed |
| US-6750215-B2 | ANTITUMOR AGENTS; ANTICANCER AGENTS | PHARMACIA & UPJOHN, S.P.A. (IT) | 2004-06-15 | — | — | US | claimed |
| US-20030073688-A1 | Novel substituted benzoxazines as integrin antagonists | POLSTER, RACHEL A. | 2003-04-17 | — | — | US | claimed |
| US-7101876-B2 | Substituted benzoxazines as integrin antagonists | PHARMACIA CORPORATION (US) | 2006-09-05 | — | — | US | disclosed |
| US-20040224948-A1 | Novel substituted benzoxazines as integrin antagonists | PHARMACIA & UPJOHN S.P.A. (IT) | 2004-11-11 | — | — | US | disclosed |
| US-6750215-B2 | ANTITUMOR AGENTS; ANTICANCER AGENTS | PHARMACIA & UPJOHN, S.P.A. (IT) | 2004-06-15 | — | — | US | disclosed |
| US-20030073688-A1 | Novel substituted benzoxazines as integrin antagonists | POLSTER, RACHEL A. | 2003-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224948-A1 | Novel substituted benzoxazines as integrin antagonists | ITGB1, ITGA1, ITGB3 | ALDH1A1 620/4885KDM4E 1485/4885ITGB3 3/4885 |
| US-20030073688-A1 | Novel substituted benzoxazines as integrin antagonists | ITGB1, ITGA1, ITGB3 | ALDH1A1 620/4885KDM4E 1485/4885ITGB3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.