Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 18/20 | 0.76 |
| ▸ | HTR1A | P08908 | 7/20 | 0.76 |
| ▸ | HTR2A | P28223 | 4/20 | 0.76 |
| ▸ | DRD2 | P14416 | 4/20 | 0.76 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6096959 | 0.86 | HTR7 (1.00) | HTR7HTR1AHTR2ADRD2HTR1B | |
| SCHEMBL6098560 | 0.83 | HTR7 (0.80) | HTR7HTR1AHTR2ADRD2HTR1B | |
| SCHEMBL6096316 | 0.70 | HTR7 (0.87) | HTR7HTR1AHTR2ADRD2HTR1B | |
| SCHEMBL6095461 | 0.68 | HTR7 (0.76) | HTR7HTR1AHTR2ADRD2HTR1B | |
| SCHEMBL6097428 | 0.68 | KEAP1 (0.39) | HTR7HTR1AHTR2ADRD2HTR1B | |
| SCHEMBL6095431 | 0.67 | HTR7 (0.72) | HTR7HTR1AHTR2ADRD2HTR1B | |
| SCHEMBL6095930 | 0.67 | HTR7 (0.88) | HTR7HTR1AHTR2ADRD2HTR1B | |
| SCHEMBL6097054 | 0.67 | HTR7 (0.72) | HTR7HTR1AHTR2ADRD2HTR1B | |
| SCHEMBL6098117 | 0.67 | HTR7 (0.72) | HTR7HTR1AHTR2ADRD2HTR1B | |
| SCHEMBL6097876 | 0.67 | HTR7 (0.72) | HTR7HTR1AHTR2ADRD2HTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | claimed |
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | HTR7 1/4885HTR1A 3/4885HTR2A 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.