Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6097043 | 1.00 | RAB9A (0.63) | RAB9AALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL21141304 | 0.86 | HPGD (0.69) | RAB9AALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL29137460 | 0.85 | RAB9A (0.67) | RAB9AALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL799431 | 0.83 | RAB9A (0.87) | RAB9AALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL8526512 | 0.83 | RAB9A (0.87) | RAB9AALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL8507346 | 0.83 | RAB9A (0.87) | RAB9AALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL12019757 | 0.83 | RAB9A (0.65) | RAB9AALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL3380039 | 0.83 | RAB9A (0.65) | RAB9AALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL4821933 | 0.81 | RAB9A (0.63) | RAB9AALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL5612318 | 0.81 | HPGD (0.68) | RAB9AALDH1A1HPGDSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7078565-B2 | Benzamide derivatives as antagonists of orexin receptors | SMITHKLINE BEECHAM PLC (GB) | 2006-07-18 | — | — | US | disclosed |
| EP-1440052-B1 | BENZAMIDE DERIVATIVES AS ANTAGONISTS OF OREXIN RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2005-12-14 | — | — | EP | disclosed |
| US-20050020584-A1 | Benzamide derivatives as antagonists of orexin receptors | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020584-A1 | Benzamide derivatives as antagonists of orexin receptors | HCRTR2, HCRTR1, OXTR | RAB9A 2725/4885ALDH1A1 1342/4885HPGD 1210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.