Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | ACACA | Q13085 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6100437 | 0.94 | KDM4E (0.56) | KDM4EHIF1AALDH1A1MEN1KMT2A | |
| Ethane SCHEMBL6101984 | 0.91 | KDM4E (0.62) | KDM4EHIF1AALDH1A1MEN1KMT2A | |
| SCHEMBL6111961 | 0.89 | KDM4E (0.53) | KDM4EHIF1AALDH1A1MEN1KMT2A | |
| SCHEMBL6097470 | 0.89 | KDM4E (0.65) | KDM4EHIF1AALDH1A1MEN1KMT2A | |
| SCHEMBL6097763 | 0.88 | KDM4E (0.64) | KDM4EHIF1AALDH1A1MEN1KMT2A | |
| SCHEMBL6099924 | 0.88 | KDM4E (0.64) | KDM4EHIF1AALDH1A1MEN1KMT2A | |
| SCHEMBL6097646 | 0.85 | KDM4E (0.61) | KDM4EHIF1AALDH1A1MEN1KMT2A | |
| Ethane SCHEMBL6100439 | 0.85 | KDM4E (0.65) | KDM4EHIF1AALDH1A1MEN1KMT2A | |
| SCHEMBL6100965 | 0.83 | KDM4E (0.56) | KDM4EHIF1AALDH1A1MEN1KMT2A | |
| SCHEMBL6102421 | 0.83 | KDM4E (0.64) | KDM4EHIF1AALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020156095-A1 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION | 2002-10-24 | — | — | US | claimed |
| US-7041664-B2 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION (US) | 2006-05-09 | — | — | US | disclosed |
| US-6894044-B2 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION (US) | 2005-05-17 | — | — | US | disclosed |
| US-6369053-B1 | CENTRAL NERVOUS SYSTEM AND PERIPHERAL DISEASES; ALSO USEFUL AS PROBES FOR THE LOCALIZATION OF CELL SURFACE RECEPTORS; NONPEPTIDE NK-3 RECEPTOR ANTAGONISTS | NEUROGEN CORPORATION | 2002-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156095-A1 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | KCNQ3, OPRK1, KCNQ1 | KDM4E 2712/4885HIF1A 3061/4885ALDH1A1 2180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.