Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 11/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.75 |
| ▸ | MAPT | P10636 | 10/20 | 0.75 |
| ▸ | NPC1 | O15118 | 6/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.75 |
| ▸ | RAB9A | P51151 | 5/20 | 0.75 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.75 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.75 |
| ▸ | RELA | Q04206 | 2/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.75 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 2/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6526030 | 0.88 | MAPT (0.70) | MEN1KMT2AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL6526033 | 0.88 | MAPT (0.70) | MEN1KMT2AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL6100618 | 0.82 | EGFR (0.56) | MEN1KMT2AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL6097501 | 0.81 | KMT2A (0.72) | MEN1KMT2AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL6100516 | 0.81 | HTT (0.74) | MEN1KMT2AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL6100523 | 0.81 | HTT (0.74) | MEN1KMT2AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL8064096 | 0.77 | MEN1 (0.61) | MEN1KMT2AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL8064094 | 0.77 | MEN1 (0.61) | MEN1KMT2AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL995085 | 0.77 | GAA (0.77) | MEN1KMT2AMAPTSMN1; SMN2RAB9A | |
| SCHEMBL8060517 | 0.75 | MEN1 (0.77) | MEN1KMT2AMAPTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053216-B2 | Modulators of Rho C activity | ICONIX PHARMACEUTICALS, INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20030171387-A1 | Modulators of Rho C activity | ENTELOS HOLDING CORP. | 2003-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171387-A1 | Modulators of Rho C activity | RHOC, ROCK1, CIT | MEN1 4684/4885KMT2A 3564/4885MAPT 4401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.