Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | TRPM2 | O94759 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6525729 | 0.88 | TRPM2 (0.76) | KMT2ACYP3A4CYP2C9TRPM2HTT | |
| SCHEMBL6525728 | 0.88 | TRPM2 (0.76) | KMT2ACYP3A4CYP2C9TRPM2HTT | |
| SCHEMBL6100523 | 0.86 | HTT (0.74) | KMT2ATRPM2HTTRECQLSMN1; SMN2 | |
| SCHEMBL6100516 | 0.86 | HTT (0.74) | KMT2ATRPM2HTTRECQLSMN1; SMN2 | |
| 4-Nitro-Cinnamanilide SCHEMBL3021597 | 0.86 | MAPT (0.72) | KMT2ASMN1; SMN2MEN1MAPTNPC1 | |
| SCHEMBL6100616 | 0.82 | KMT2A (0.64) | KMT2ACYP3A4CYP2C9TRPM2HTT | |
| SCHEMBL6097507 | 0.81 | MEN1 (0.75) | KMT2AHTTRECQLSMN1; SMN2MEN1 | |
| SCHEMBL15306486 | 0.81 | MMP1 (0.69) | KMT2ASMN1; SMN2MEN1MAPTNPC1 | |
| SCHEMBL3021602 | 0.81 | MMP1 (0.69) | KMT2ASMN1; SMN2MEN1MAPTNPC1 | |
| 4-Nitro-(4'-Nitro)Cinnamanilide SCHEMBL5315660 | 0.79 | KMT2A (0.70) | KMT2AHTTSMN1; SMN2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053216-B2 | Modulators of Rho C activity | ICONIX PHARMACEUTICALS, INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20030171387-A1 | Modulators of Rho C activity | ENTELOS HOLDING CORP. | 2003-09-11 | — | — | US | disclosed |
| WO-2003043961-A2 | MODULATORS OF RHO C ACTIVITY | ICONIX PHARMACEUTICALS, INC. (US) | 2003-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171387-A1 | Modulators of Rho C activity | RHOC, ROCK1, CIT | KMT2A 3564/4885CYP3A4 2850/4885CYP2C9 2362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.