Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.74 |
| ▸ | RECQL | P46063 | 1/20 | 0.74 |
| ▸ | MMP1 | P03956 | 10/20 | 0.69 |
| ▸ | MMP2 | P08253 | 10/20 | 0.69 |
| ▸ | MMP9 | P14780 | 10/20 | 0.69 |
| ▸ | EGFR | P00533 | 6/20 | 0.69 |
| ▸ | MAOA | P21397 | 1/20 | 0.69 |
| ▸ | MAOB | P27338 | 1/20 | 0.69 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.63 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.62 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.62 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.61 |
| ▸ | TRPA1 | O75762 | 5/20 | 0.60 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6100523 | 1.00 | HTT (0.74) | HTTRECQLMMP1MMP2MMP9 | |
| SCHEMBL6097501 | 0.86 | KMT2A (0.72) | HTTRECQLMMP1MMP2MMP9 | |
| SCHEMBL28605928 | 0.85 | MMP1 (0.64) | MMP1MMP2MMP9EGFRNR1H4 | |
| SCHEMBL28605929 | 0.85 | MMP1 (0.64) | MMP1MMP2MMP9EGFRNR1H4 | |
| SCHEMBL294403 | 0.84 | TRPM2 (0.83) | RECQLMMP1MMP2MMP9EGFR | |
| SCHEMBL294402 | 0.84 | TRPM2 (0.83) | RECQLMMP1MMP2MMP9EGFR | |
| N-Phenylcinnamamide SCHEMBL3667414 | 0.82 | MMP1 (1.00) | MMP1MMP2MMP9EGFRMAOA | |
| N-Phenylcinnamamide SCHEMBL4205896 | 0.82 | MMP1 (1.00) | MMP1MMP2MMP9EGFRMAOA | |
| SCHEMBL10492424 | 0.82 | MMP1 (0.80) | MMP1MMP2MMP9EGFRMAOA | |
| SCHEMBL10492426 | 0.82 | MMP1 (0.80) | MMP1MMP2MMP9EGFRMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053216-B2 | Modulators of Rho C activity | ICONIX PHARMACEUTICALS, INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20030171387-A1 | Modulators of Rho C activity | ENTELOS HOLDING CORP. | 2003-09-11 | — | — | US | disclosed |
| WO-2003043961-A2 | MODULATORS OF RHO C ACTIVITY | ICONIX PHARMACEUTICALS, INC. (US) | 2003-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171387-A1 | Modulators of Rho C activity | RHOC, ROCK1, CIT | HTT 3522/4885RECQL 479/4885MMP1 2062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.