Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30201832 | 0.82 | SMN1; SMN2 (0.60) | KDM4ERAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL16234345 | 0.82 | KDM4E (0.51) | ABCG2KDM4ERAB9AMAPTSMN1; SMN2 | |
| SCHEMBL68891 | 0.82 | KDM4E (0.51) | ABCG2KDM4ERAB9AMAPTSMN1; SMN2 | |
| SCHEMBL28049817 | 0.81 | TDP1 (0.55) | KDM4ETDP1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL24951256 | 0.81 | KDM4E (0.48) | ABCG2KDM4ERAB9AMAPTSMN1; SMN2 | |
| SCHEMBL30819462 | 0.81 | KDM4E (0.48) | ABCG2KDM4ERAB9AMAPTSMN1; SMN2 | |
| SCHEMBL5255504 | 0.81 | IKBKB (0.66) | ABCG2KDM4ERAB9AMAPTSMN1; SMN2 | |
| SCHEMBL31105839 | 0.81 | KDM4E (0.57) | ABCG2KDM4ERAB9AMAPTSMN1; SMN2 | |
| SCHEMBL20098513 | 0.81 | KDM4E (0.57) | ABCG2KDM4ERAB9AMAPTSMN1; SMN2 | |
| SCHEMBL6603045 | 0.81 | KDM4E (0.51) | ABCG2KDM4ERAB9AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7041664-B2 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION (US) | 2006-05-09 | — | — | US | disclosed |
| US-6894044-B2 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION (US) | 2005-05-17 | — | — | US | disclosed |
| US-20040229907-A1 | 2-Aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION, A CORPORATION OF THE STATE OF DELAWARE | 2004-11-18 | — | — | US | disclosed |
| US-20020156095-A1 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | NEUROGEN CORPORATION | 2002-10-24 | — | — | US | disclosed |
| US-6369053-B1 | CENTRAL NERVOUS SYSTEM AND PERIPHERAL DISEASES; ALSO USEFUL AS PROBES FOR THE LOCALIZATION OF CELL SURFACE RECEPTORS; NONPEPTIDE NK-3 RECEPTOR ANTAGONISTS | NEUROGEN CORPORATION | 2002-04-09 | — | — | US | disclosed |
| WO-2000064877-A1 | 2-AMINOQUINOLINECARBOXAMIDES: NEUROKININ RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 2000-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229907-A1 | 2-Aminoquinolinecarboxamides: neurokinin receptor ligands | OPRL1, OPRK1, KCNQ3 | ABCG2 476/4885KDM4E 3541/4885TDP1 2627/4885 |
| US-20020156095-A1 | 2-aminoquinolinecarboxamides: neurokinin receptor ligands | KCNQ3, OPRK1, KCNQ1 | ABCG2 570/4885KDM4E 2712/4885TDP1 2704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.