Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 10/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6097398 | 0.83 | HTR7 (0.63) | HTR7HTR1AHTR2AGAA | |
| SCHEMBL6099295 | 0.79 | HTR7 (0.62) | HTR7HTR1AHTR2AGAA | |
| SCHEMBL6097493 | 0.76 | HTR7 (0.55) | HTR7HTR1AHTR2AKMT2AALDH1A1 | |
| SCHEMBL6098775 | 0.75 | HTR7 (0.78) | HTR7HTR1AHTR2AKMT2A | |
| SCHEMBL6097856 | 0.68 | HTR7 (0.35) | HTR7HTR1AHTR2A | |
| SCHEMBL12688444 | 0.66 | KMT2A (0.41) | HTR2AKMT2AFBP1ALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL7977476 | 0.66 | HTR6 (0.40) | KMT2AFBP1ALDH1A1GAA | |
| SCHEMBL19692906 | 0.65 | HTR6 (0.41) | HTR7HTR1AHTR2AGAA | |
| SCHEMBL29650249 | 0.65 | HTR6 (0.41) | HTR7HTR1AHTR2AGAA | |
| SCHEMBL29038809 | 0.65 | ITGB1 (0.49) | KMT2AFBP1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | HTR7 1/4885HTR1A 3/4885HTR2A 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.