Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.37 |
| ▸ | OGA | O60502 | 2/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 3/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | FPR3 | P25089 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HTR1E | P28566 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6097963 | 0.85 | HRH3 (0.44) | HRH4OGAPTGDRHTR2AHTR2C | |
| SCHEMBL6098986 | 0.82 | DRD3 (0.45) | HRH4HTR2AHTR2CHTR1ADRD3 | |
| SCHEMBL6100280 | 0.79 | HRH4 (0.44) | HRH4HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL6099758 | 0.79 | HRH3 (0.45) | HRH4HTR2AHTR2CHTR2BHTR1A | |
| SCHEMBL6099613 | 0.79 | HRH4 (0.56) | HRH4HTR2AHTR2CHTR2BHTR1D | |
| SCHEMBL6099835 | 0.74 | HTR2C (0.55) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| SCHEMBL30138420 | 0.74 | HTR2C (0.55) | HTR2AHTR2CHTR2BHTR1ADRD3 | |
| SCHEMBL6099906 | 0.74 | HRH3 (0.44) | HRH4HTR1AHRH3 | |
| SCHEMBL6098835 | 0.73 | MAP4K4 (0.48) | HRH4HTR2AHTR2CHTR1ADRD3 | |
| SCHEMBL6101931 | 0.73 | HTR1A (0.47) | HRH4HTR2AHTR2CHTR1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7009051-B2 | 4-(2-pyridyl) piperazines having 5HT7 receptor agonist activity | PFIZER INC (US) | 2006-03-07 | — | — | US | claimed |
| US-20040014769-A1 | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity | PFIZER INC. | 2004-01-22 | — | — | US | claimed |
| EP-1254905-B1 | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity | PFIZER PROD INC (US) | 2003-12-17 | — | — | EP | claimed |
| US-20030008880-A1 | 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity | PFIZER INC. | 2003-01-09 | — | — | US | claimed |
| EP-1254905-A1 | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity | Pfizer Products Inc. (US) | 2002-11-06 | — | — | EP | claimed |
| US-7009051-B2 | 4-(2-pyridyl) piperazines having 5HT7 receptor agonist activity | PFIZER INC (US) | 2006-03-07 | — | — | US | disclosed |
| US-20040014769-A1 | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity | PFIZER INC. | 2004-01-22 | — | — | US | disclosed |
| EP-1254905-B1 | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity | PFIZER PROD INC (US) | 2003-12-17 | — | — | EP | disclosed |
| US-20030008880-A1 | 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity | PFIZER INC. | 2003-01-09 | — | — | US | disclosed |
| EP-1254905-A1 | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity | Pfizer Products Inc. (US) | 2002-11-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014769-A1 | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity | HTR7, HTR1A, HTR2C | HRH4 170/4885OGA 4655/4885PTGDR 119/4885 |
| US-20030008880-A1 | 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity | HTR7, HTR1A, HTR2C | HRH4 145/4885OGA 4511/4885PTGDR 113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.