Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | GLP1R | P43220 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6100280 | 0.90 | HRH4 (0.44) | HRH4ALDH1A1SMN1; SMN2HTTKDM4E | |
| SCHEMBL6098986 | 0.88 | DRD3 (0.45) | HRH3HRH4HTR2AHTR2CHTR1A | |
| SCHEMBL6099613 | 0.87 | HRH4 (0.56) | HRH3HRH4ALDH1A1TSHRHTR2A | |
| SCHEMBL6098835 | 0.86 | MAP4K4 (0.48) | HRH4ALDH1A1SMN1; SMN2HTTKDM4E | |
| SCHEMBL6100140 | 0.85 | NPC1 (0.59) | HRH3HRH4ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6097963 | 0.84 | HRH3 (0.44) | HRH3HRH4ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6101931 | 0.83 | HTR1A (0.47) | HRH3HRH4ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6099980 | 0.83 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2HTTKDM4ELMNA | |
| SCHEMBL6099216 | 0.82 | GLP1R (0.41) | HRH3HRH4ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6096996 | 0.82 | KDM4E (0.52) | ALDH1A1SMN1; SMN2HTTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7009051-B2 | 4-(2-pyridyl) piperazines having 5HT7 receptor agonist activity | PFIZER INC (US) | 2006-03-07 | — | — | US | claimed |
| US-20040014769-A1 | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity | PFIZER INC. | 2004-01-22 | — | — | US | claimed |
| EP-1254905-B1 | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity | PFIZER PROD INC (US) | 2003-12-17 | — | — | EP | claimed |
| US-20030008880-A1 | 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity | PFIZER INC. | 2003-01-09 | — | — | US | claimed |
| EP-1254905-A1 | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity | Pfizer Products Inc. (US) | 2002-11-06 | — | — | EP | claimed |
| US-7009051-B2 | 4-(2-pyridyl) piperazines having 5HT7 receptor agonist activity | PFIZER INC (US) | 2006-03-07 | — | — | US | disclosed |
| US-20040014769-A1 | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity | PFIZER INC. | 2004-01-22 | — | — | US | disclosed |
| EP-1254905-B1 | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity | PFIZER PROD INC (US) | 2003-12-17 | — | — | EP | disclosed |
| US-20030008880-A1 | 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity | PFIZER INC. | 2003-01-09 | — | — | US | disclosed |
| EP-1254905-A1 | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity | Pfizer Products Inc. (US) | 2002-11-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014769-A1 | 4-(2-Pyridyl)piperazines having 5HT7 receptor agonist activity | HTR7, HTR1A, HTR2C | HRH3 203/4885HRH4 170/4885ALDH1A1 1531/4885 |
| US-20030008880-A1 | 4-(2-Pyridyl) piperizines having 5HT7 receptor agonist activity | HTR7, HTR1A, HTR2C | HRH3 196/4885HRH4 145/4885ALDH1A1 1581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.