Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 19/20 | 0.64 |
| ▸ | HTR1A | P08908 | 11/20 | 0.64 |
| ▸ | HTR2A | P28223 | 11/20 | 0.64 |
| ▸ | DRD4 | P21917 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5371091 | 0.90 | DRD2 (0.72) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL6108811 | 0.84 | DRD2 (0.61) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL5370235 | 0.83 | HTR1A (0.69) | DRD2HTR1AHTR2ADRD3HTR7 | |
| SCHEMBL5374803 | 0.82 | DRD2 (0.71) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL5375484 | 0.82 | DRD2 (0.71) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL5367098 | 0.81 | DRD2 (0.76) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL5363742 | 0.81 | DRD2 (0.67) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL4759675 | 0.81 | HTR1A (0.75) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL5378995 | 0.80 | DRD2 (0.87) | DRD2HTR1AHTR2ADRD4DRD3 | |
| SCHEMBL6103085 | 0.80 | DRD2 (0.69) | DRD2HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006090272-A1 | ISOQUINOLINE [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2006-08-31 | — | — | WO | claimed |
| WO-2006090272-A1 | ISOQUINOLINE [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2006-08-31 | — | — | WO | disclosed |