Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 4/20 | 0.37 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618266 | 0.91 | KMT2A (0.48) | KMT2APOLBGAAMEN1NPC1 | |
| SCHEMBL4637629 | 0.85 | PIK3CD (0.41) | KMT2AMEN1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL4617625 | 0.84 | PIK3CD (0.42) | PIK3CDPIK3CBPIK3CGBRD4SFRP1 | |
| SCHEMBL6099337 | 0.84 | USP30 (0.45) | BRD4SFRP1ALDH1A1HTR2CHTR6 | |
| SCHEMBL4618273 | 0.83 | CNR2 (0.45) | POLBPIK3CDPIK3CBPIK3CGBRD4 | |
| SCHEMBL6101911 | 0.79 | PIK3CD (0.39) | GAAPIK3CDPIK3CBPIK3CGBRD4 | |
| SCHEMBL4616241 | 0.76 | PIK3CD (0.39) | KMT2AMEN1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL6101011 | 0.75 | BRD4 (0.42) | GAAPIK3CDPIK3CBPIK3CGBRD4 | |
| SCHEMBL4617752 | 0.75 | HTR1A (0.47) | KMT2AMEN1NPC1HTR7CNR2 | |
| SCHEMBL4617093 | 0.74 | CNR2 (0.45) | KMT2AMEN1NPC1HTR7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | claimed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | KMT2A 3832/4885POLB 4876/4885GAA 4113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.