Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 7/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6110129 | 0.92 | DPP4 (0.42) | DPP4LMNAPLA2G2AMAPK8THRA | |
| SCHEMBL6108314 | 0.90 | PGR (0.39) | DPP4MAPK8THRATHRB | |
| SCHEMBL6108888 | 0.88 | RORA (0.36) | DPP4LMNAKDM4EMAPK8 | |
| SCHEMBL6109048 | 0.88 | NPC1 (0.41) | DPP4LMNAKDM4E | |
| SCHEMBL6108268 | 0.88 | DPP4 (0.35) | DPP4LMNA | |
| SCHEMBL6108552 | 0.87 | MAPK8 (0.31) | DPP4MAPK8 | |
| SCHEMBL6107104 | 0.87 | RORA (0.36) | DPP4 | |
| SCHEMBL5237142 | 0.86 | DPP4 (0.41) | DPP4LMNAKDM4EPOLBMAPK1 | |
| SCHEMBL6107387 | 0.86 | HTT (0.35) | DPP4LMNAKDM4E | |
| SCHEMBL6109932 | 0.86 | KDM4E (0.34) | DPP4KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7034039-B2 | Fused heterocyclic compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-25 | — | — | US | disclosed |