Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21812728 | 0.83 | GAA (0.70) | GAAALDH1A1LMNASMN1; SMN2MCOLN3 | |
| SCHEMBL6110753 | 0.79 | HSD11B1 (0.59) | MCOLN3TRPV4HSD11B1 | |
| SCHEMBL6034697 | 0.78 | USP5 (0.49) | GAAALDH1A1LMNATRPV4TSHR | |
| SCHEMBL19869952 | 0.77 | ALDH1A1 (0.57) | GAAALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL19869965 | 0.76 | GAA (0.62) | GAAALDH1A1SMN1; SMN2MCOLN3TSHR | |
| SCHEMBL25188793 | 0.75 | HTR2A (0.55) | GAAALDH1A1 | |
| SCHEMBL17843485 | 0.73 | GAA (0.66) | GAAALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL6111481 | 0.73 | HSD11B1 (0.48) | HSD11B1NPY5RMCHR1RORC | |
| SCHEMBL21812733 | 0.73 | LMNA (0.46) | GAAALDH1A1LMNAHTTTRPV4 | |
| SCHEMBL6111072 | 0.72 | EPHX2 (0.48) | GAALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006134481-A1 | INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1 | PFIZER INC. (US) | 2006-12-21 | — | — | WO | disclosed |