Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | NOS2 | P35228 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | ARG1 | P05089 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL6113021 | 1.00 | MEN1 (0.45) | MEN1KMT2ABLMNOS2NOS3 | |
| Proline SCHEMBL523389 | 0.92 | PRCP (0.42) | MEN1KMT2ABLMNOS2NOS3 | |
| Proline SCHEMBL462225 | 0.91 | BLM (0.52) | MEN1KMT2ABLMNOS2NOS3 | |
| D-Proline SCHEMBL21462052 | 0.91 | BLM (0.52) | MEN1KMT2ABLMNOS2NOS3 | |
| Proline SCHEMBL462226 | 0.91 | BLM (0.52) | MEN1KMT2ABLMNOS2NOS3 | |
| Proline SCHEMBL10141181 | 0.91 | — | — | |
| Proline SCHEMBL10141185 | 0.91 | — | — | |
| Proline SCHEMBL718906 | 0.91 | BLM (0.52) | MEN1KMT2ABLMNOS2NOS3 | |
| Proline SCHEMBL13248912 | 0.91 | — | — | |
| Proline SCHEMBL2939 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2460826-B1 | MOTILIN-LIKE PEPTIDE COMPOUND HAVING TRANSMUCOSAL ABSORBABILITY IMPARTED THERETO | DAIICHI SANKYO CO LTD (JP) | 2017-10-18 | — | — | EP | disclosed |
| US-8710184-B2 | Motilin-like peptide compound having transmucosal absorbability imparted thereto | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-04-29 | — | — | US | disclosed |
| EP-2460826-A1 | MOTILIN-LIKE PEPTIDE COMPOUND HAVING TRANSMUCOSAL ABSORBABILITY IMPARTED THERETO | Daiichi Sankyo Company, Limited (JP) | 2012-06-06 | — | — | EP | disclosed |
| US-20120129762-A1 | MOTILIN-LIKE PEPTIDE COMPOUND HAVING TRANSMUCOSAL ABSORBABILITY IMPARTED THERETO | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129762-A1 | MOTILIN-LIKE PEPTIDE COMPOUND HAVING TRANSMUCOSAL ABSORBABILITY IMPARTED THERETO | MLNR, MLN, VIP | MEN1 35/4885KMT2A 4371/4885BLM 3372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.