Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL29983942 | 0.87 | — | — | |
| Guanidine SCHEMBL5613752 | 0.87 | — | — | |
| Guanidine SCHEMBL165720 | 0.87 | NOS2 (0.42) | — | |
| Guanidine SCHEMBL11330173 | 0.87 | — | — | |
| Guanidine SCHEMBL2003 | 0.87 | — | — | |
| Guanidine SCHEMBL3390300 | 0.82 | — | — | |
| Guanidine SCHEMBL25310528 | 0.80 | — | — | |
| Guanidine SCHEMBL8024162 | 0.80 | — | — | |
| Guanidine SCHEMBL10418561 | 0.80 | — | — | |
| Guanidine SCHEMBL9110704 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643332-B1 | METHOD FOR BUFFERING A CHEMICAL OR BIOLOGICAL COMPOSITION | SACHEM INC (US) | 2014-10-22 | — | — | EP | disclosed |
| EP-2643332-A2 | METHOD FOR BUFFERING A CHEMICAL OR BIOLOGICAL COMPOSITION | Sachem, Inc. (US) | 2013-10-02 | — | — | EP | disclosed |
| US-8361779-B2 | Buffer compounds | SACHEM, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| WO-2012071102-A2 | BUFFER COMPOUNDS | SACHEM, INC. (US) | 2012-05-31 | — | — | WO | disclosed |
| US-20120129240-A1 | BUFFER COMPOUNDS | SACHEM, INC. | 2012-05-24 | — | — | US | disclosed |