Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanidine SCHEMBL28214616 | 0.94 | — | — | |
| Guanidine SCHEMBL5613752 | 0.93 | — | — | |
| Guanidine SCHEMBL29983942 | 0.93 | — | — | |
| Guanidine SCHEMBL2003 | 0.93 | — | — | |
| Guanidine SCHEMBL11330173 | 0.93 | — | — | |
| Guanidine SCHEMBL165720 | 0.93 | NOS2 (0.42) | — | |
| Guanidine SCHEMBL25310528 | 0.86 | — | — | |
| Guanidine SCHEMBL66976 | 0.86 | — | — | |
| Guanidine SCHEMBL10418561 | 0.86 | — | — | |
| Guanidine SCHEMBL3349156 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3894417-B1 | NOVEL GALLIUM COMPOUNDS AND THEIR USE | UNIV BIELEFELD (DE) | 2022-12-07 | — | — | EP | disclosed |
| US-11330999-B2 | Hyperpolarized and deuterium exchanged hyperpolarized13C and 15N-labeled xanthine, arginine, glutamine, and urea probes | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2022-05-17 | — | — | US | disclosed |
| US-20200260983-A1 | HYPERPOLARIZED AND DEUTERIUM EXCHANGED HYPERPOLARIZED13C AND 15N-LABELED XANTHINE, ARGININE, GLUTAMINE, AND UREA PROBES | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2020-08-20 | — | — | US | disclosed |
| EP-3692013-A1 | HYPERPOLARIZED AND DEUTERIUM EXCHANGED HYPERPOLARIZED13C AND 15N-LABELED XANTHINE, ARGININE, GLUTAMINE, AND UREA PROBES | Memorial Sloan-Kettering Cancer Center (US) | 2020-08-12 | — | — | EP | disclosed |
| WO-2019055358-A1 | HYPERPOLARIZED AND DEUTERIUM EXCHANGED HYPERPOLARIZED13C AND 15N-LABELED XANTHINE, ARGININE, GLUTAMINE, AND UREA PROBES | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2019-03-21 | — | — | WO | disclosed |
| US-8853417-B2 | Non-halogen activating agent used as flux | HUNAN ASTAR BIOTECHNOLOGY LTD. (CN) | 2014-10-07 | — | — | US | disclosed |
| CN-104053458-A | Hydrogel materials comprising eluting ceragenin compounds | UNIV BRIGHAM YOUNG | 2014-09-17 | — | — | CN | disclosed |
| CN-104039369-A | Hydrophobic ceragenin compounds and devices incorporating same | UNIV BRIGHAM YOUNG | 2014-09-10 | — | — | CN | disclosed |
| US-20120142938-A1 | Non-halogen activating agent used as flux | HUNAN ASTAR BIOTECHNOLOGY LTD (CN) | 2012-06-07 | — | — | US | disclosed |