Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.33 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | WDR5 | P61964 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6121013 | 0.91 | WDR5 (0.37) | BRAFGRIN2BWDR5 | |
| SCHEMBL6120439 | 0.88 | PTGES2 (0.35) | BTKBRAFEGFRCSNK1EGRIN2B | |
| SCHEMBL6121578 | 0.87 | BRAF (0.33) | BTKBRAFEGFRCSNK1EGRIN2B | |
| SCHEMBL6120657 | 0.87 | PTGES2 (0.37) | BTKBRAFEGFRCSNK1E | |
| SCHEMBL6120639 | 0.85 | WDR5 (0.37) | BRAFEGFRWDR5 | |
| SCHEMBL6120427 | 0.84 | BRAF (0.35) | BRAFWDR5 | |
| SCHEMBL6121300 | 0.82 | PTGES2 (0.38) | BTKBRAFEGFR | |
| SCHEMBL6120796 | 0.82 | CSNK1D (0.39) | BTKEGFRCSNK1E | |
| SCHEMBL6121002 | 0.81 | BRAF (0.34) | BRAFWDR5 | |
| SCHEMBL6120760 | 0.80 | BTK (0.39) | BTKEGFRCSNK1ECA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012067664-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-05-24 | — | — | WO | disclosed |