Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 7/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6120670 | 0.94 | PTGES2 (0.37) | BRAFPTGES2WDR5ACLY | |
| SCHEMBL6120439 | 0.93 | PTGES2 (0.35) | BRAFPTGES2JAK2 | |
| SCHEMBL6120617 | 0.93 | BRAF (0.32) | BRAFPTGES2WDR5ACLY | |
| SCHEMBL6121823 | 0.92 | CYP3A4 (0.36) | BRAFPTGES2JAK2WDR5 | |
| SCHEMBL6121996 | 0.90 | JAK2 (0.32) | BRAFJAK2WDR5 | |
| SCHEMBL6121104 | 0.90 | BRAF (0.34) | BRAF | |
| SCHEMBL6120642 | 0.89 | BRAF (0.38) | BRAFJAK2WDR5ACLY | |
| SCHEMBL6121300 | 0.87 | PTGES2 (0.38) | BRAFPTGES2 | |
| SCHEMBL6120692 | 0.86 | TP53 (0.37) | BRAF | |
| SCHEMBL6120874 | 0.86 | BRAF (0.36) | BRAFPTGES2WDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012067664-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-05-24 | — | — | WO | disclosed |