Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 3/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.37 |
| ▸ | EDNRB | P24530 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6120998 | 0.93 | ACLY (0.43) | ACLYKMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL2994042 | 0.86 | BRAF (0.44) | BRAF | |
| SCHEMBL17332238 | 0.85 | BRD4 (0.38) | KMT2AMAPTALDH1A1LMNABRAF | |
| SCHEMBL6121072 | 0.84 | MAPT (0.36) | MAPTALDH1A1BRAF | |
| SCHEMBL3000942 | 0.81 | BRAF (0.43) | BRAF | |
| SCHEMBL2994199 | 0.80 | BRAF (0.46) | BRAF | |
| SCHEMBL6120949 | 0.80 | L3MBTL1 (0.43) | KMT2AMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL17332257 | 0.79 | BRAF (0.37) | LMNABRAFHPGD | |
| SCHEMBL2987982 | 0.78 | BRAF (0.44) | MAPTBRAFTP53 | |
| SCHEMBL2998731 | 0.78 | BRAF (0.46) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012067664-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-05-24 | — | — | WO | disclosed |