Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 2/20 | 0.36 |
| ▸ | PTGES2 | Q9H7Z7 | 8/20 | 0.34 |
| ▸ | BRAF | P15056 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6121078 | 0.94 | PTGES2 (0.35) | WDR5PTGES2BRAF | |
| SCHEMBL6121823 | 0.93 | CYP3A4 (0.36) | WDR5PTGES2BRAFCYP2C9CYP3A4 | |
| SCHEMBL6120643 | 0.92 | BRAF (0.34) | WDR5PTGES2BRAFCYP2C9CYP3A4 | |
| SCHEMBL6120657 | 0.91 | PTGES2 (0.37) | PTGES2BRAFJAK2 | |
| SCHEMBL6120874 | 0.90 | BRAF (0.36) | WDR5PTGES2BRAFCYP2C9CYP3A4 | |
| SCHEMBL6121195 | 0.89 | BRAF (0.32) | WDR5PTGES2BRAFCYP2C9CYP3A4 | |
| SCHEMBL6121013 | 0.87 | WDR5 (0.37) | WDR5BRAFCYP2C9CYP3A4CYP2C19 | |
| SCHEMBL6121734 | 0.87 | CYP2C9 (0.33) | WDR5PTGES2BRAFCYP2C9CYP3A4 | |
| SCHEMBL6120989 | 0.86 | BRAF (0.34) | WDR5PTGES2BRAFCYP2C9CYP3A4 | |
| SCHEMBL6121072 | 0.86 | MAPT (0.36) | BRAFCYP2C9CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012067664-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-05-24 | — | — | WO | disclosed |