Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL16752517 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL363366 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL8557756 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL793773 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL793772 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL10796092 | 1.00 | TSHR (0.90) | — | |
| Maleic Acid SCHEMBL7337222 | 1.00 | TSHR (0.90) | — | |
| Maleic Acid SCHEMBL4617429 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL12474192 | 1.00 | TSHR (0.90) | — | |
| Fumaric Acid SCHEMBL363367 | 1.00 | TSHR (0.90) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 343 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118159266-A | Pharmaceutical combination comprising a capsid protein inhibitor and a reverse transcriptase inhibitor | 正大天晴药业集团股份有限公司 | 2024-06-07 | — | — | CN | claimed |
| US-11926636-B2 | Crystalline forms of lorlatinib maleate | PFIZER INC. (US) | 2024-03-12 | — | — | US | claimed |
| CN-117510500-A | Preparation method of asperazepanones alkaloid and application of asperazepanones alkaloid as anti-inflammatory drug | 中国海洋大学 | 2024-02-06 | — | — | CN | claimed |
| US-20230271958-A1 | SALT AND CRYSTAL FORM OF DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATE | NANJING CHIA TAI TIANQING PHARMACEUTICAL CO., LTD. (CN) | 2023-08-31 | — | — | US | claimed |
| CN-116478116-A | Crystallization method for preparing monodisperse blocky michelia lactone dimethylamine fumarate hydrate | 天津大学 | 2023-07-25 | — | — | CN | claimed |
| US-20230226049-A1 | ACALABRUTINIB MALEATE DOSAGE FORMS | ACERTA PHARMA B.V. (NL) | 2023-07-20 | — | — | US | claimed |
| CN-116367834-A | Pharmaceutical combinations comprising a capsid protein inhibitor and a nucleoside analogue | 正大天晴药业集团股份有限公司 | 2023-06-30 | — | — | CN | claimed |
| EP-4167968-A1 | ACALABRUTINIB MALEATE DOSAGE FORMS | Acerta Pharma B.V. (NL) | 2023-04-26 | — | — | EP | claimed |
| CN-115916161-A | Acaracitinib maleate dosage form | 安塞塔制药公司 | 2023-04-04 | — | — | CN | claimed |
| CN-115843298-A | Salt and crystal form of dihydropyrido [2,3-d ] pyrimidone derivative | 南京正大天晴制药有限公司 | 2023-03-24 | — | — | CN | claimed |
| WO-2006096802-A1 | AMORPHOUS TEGASEROD MALEATE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2006-09-14 | — | — | WO | claimed |
| US-5658888-A | ENTEROKINESIS STIMULATING ACTION | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1997-08-19 | — | — | US | claimed |
| US-4912102-A | Calcium antagonist activity | HOFFMANN-LA ROCHE INC. (US) | 1990-03-27 | — | — | US | claimed |
| US-4694003-A | Method of treating depression with 5-(aminoalkyl)-11-phenyl-5H-dibenzo(b,e)(1,4) diazepines | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-09-15 | — | — | US | claimed |
| EP-0111588-B1 | PHYSICALLY-AMELIORATED STYRENE POLYMER/THERMOPLASTIC ELASTOMER POLYBLENDS | THE DOW CHEMICAL COMPANY (US) | 1987-09-09 | — | — | EP | claimed |
| US-4659776-A | STRESS, CRACK RESISTANCE | THE DOW CHEMICAL COMPANY (US) | 1987-04-21 | — | — | US | claimed |
| EP-0066987-B1 | N-(ARYLOXYALKYL)-N'-(AMINO-ALKYL) UREAS | A.H. ROBINS COMPANY, INCORPORATED (US) | 1986-08-27 | — | — | EP | claimed |
| US-4558155-A | N-(Aryloxyalkyl)-N'-(aminoalkyl)thioureas | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-12-10 | — | — | US | claimed |
| EP-0111588-A1 | Physically-ameliorated styrene polymer/thermoplastic elastomer polyblends | THE DOW CHEMICAL COMPANY (US) | 1984-06-27 | — | — | EP | claimed |
| EP-0066987-A2 | N-(aryloxyalkyl)-N'-(amino-alkyl) ureas | A.H. ROBINS COMPANY, INCORPORATED (US) | 1982-12-15 | — | — | EP | claimed |