Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.37 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.31 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.31 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.31 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17194144 | 0.78 | ALDH1A1 (0.42) | ROCK2ROCK1CDC42BPACDC42BPBTSHR | |
| SCHEMBL28381748 | 0.78 | LOXL2 (0.41) | ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL9230994 | 0.76 | LRRK2 (0.40) | ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL20375313 | 0.76 | SRC (0.39) | ROCK2ROCK1CDC42BPACDC42BPBTSHR | |
| SCHEMBL11829926 | 0.76 | KDM4E (0.44) | — | |
| SCHEMBL8440146 | 0.76 | KDM4E (0.52) | ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL30336388 | 0.76 | SRC (0.39) | ROCK2ROCK1CDC42BPACDC42BPBTSHR | |
| SCHEMBL13174924 | 0.76 | SRC (0.39) | ROCK2ROCK1CDC42BPACDC42BPBTSHR | |
| Hydrochloric Acid SCHEMBL8435753 | 0.74 | KDM4E (0.50) | ROCK2ROCK1CDC42BPACDC42BPB | |
| Hydrochloric Acid SCHEMBL8438819 | 0.74 | KDM4E (0.50) | ROCK2ROCK1CDC42BPACDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1930319-B1 | Proline derivatives and use thereof as drugs | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-05-02 | — | — | EP | disclosed |