Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.37 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17194144 | 0.78 | ALDH1A1 (0.42) | SRCROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL28381748 | 0.78 | LOXL2 (0.41) | ROCK2ROCK1CDC42BPACDC42BPBAPP | |
| SCHEMBL9224255 | 0.77 | ALDH1A1 (0.44) | MAP2K1TSHRRECQL | |
| SCHEMBL8440146 | 0.76 | KDM4E (0.52) | ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL9230994 | 0.76 | LRRK2 (0.40) | ROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL11829926 | 0.76 | KDM4E (0.44) | SRC | |
| SCHEMBL30336388 | 0.76 | SRC (0.39) | SRCROCK2ROCK1CDC42BPACDC42BPB | |
| SCHEMBL6125232 | 0.76 | ROCK2 (0.37) | ROCK2ROCK1CDC42BPACDC42BPBTSHR | |
| SCHEMBL13174924 | 0.76 | SRC (0.39) | SRCROCK2ROCK1CDC42BPACDC42BPB | |
| Hydrochloric Acid SCHEMBL8435753 | 0.74 | KDM4E (0.50) | ROCK2ROCK1CDC42BPACDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3345907-B1 | PYRAZOLO[3,4-D]PYRIMIDINE COMPOUNDS OR SALTS THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2020-04-22 | — | — | EP | disclosed |
| EP-3345907-A1 | NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUND OR SALT THEREOF | Taiho Pharmaceutical Co., Ltd. (JP) | 2018-07-11 | — | — | EP | disclosed |