Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23081075 | 0.89 | PLA2G2C (0.43) | KDM4EALDH1A1NPC1KDM4CSIGMAR1 | |
| SCHEMBL26016842 | 0.89 | KDM4E (0.43) | KDM4EALDH1A1NPC1KDM4CSIGMAR1 | |
| SCHEMBL18713105 | 0.82 | KDM4E (0.45) | KDM4EALDH1A1KDM4CSIGMAR1TDP1 | |
| SCHEMBL24568671 | 0.76 | KDM4E (0.66) | KDM4EALDH1A1KDM4CSIGMAR1TDP1 | |
| SCHEMBL22507715 | 0.74 | L3MBTL1 (0.47) | TDP1KMT2ACA1MEN1 | |
| SCHEMBL21142831 | 0.74 | L3MBTL1 (0.47) | TDP1KMT2ACA1MEN1 | |
| SCHEMBL25106912 | 0.74 | L3MBTL1 (0.43) | TDP1KMT2ACA1MEN1 | |
| SCHEMBL23691156 | 0.72 | ALDH1A1 (0.56) | KDM4EALDH1A1NPC1KDM4CUSP2 | |
| SCHEMBL10053024 | 0.71 | TDP1 (0.66) | KDM4EALDH1A1NPC1TDP1KMT2A | |
| SCHEMBL23081196 | 0.71 | HTT (0.55) | ALDH1A1KMT2ACTSSHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1930319-B1 | Proline derivatives and use thereof as drugs | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-05-02 | — | — | EP | disclosed |