SCHEMBL612643

SCHEMBL612643

CCn1c(=O)[nH]c2ccccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 1.00
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00
SMN1; SMN2 Q16637 3/20 0.62
ALDH1A1 P00352 3/20 0.62
LMNA P02545 4/20 0.58
HTT P42858 2/20 0.58
TSHR P16473 2/20 0.58
HPGD P15428 2/20 0.58
MAPT P10636 1/20 0.58
MAPK1 P28482 1/20 0.58
TDP1 Q9NUW8 1/20 0.58
RAB9A P51151 1/20 0.57
CYP3A4 P08684 1/20 0.54
CYP2D6 P10635 1/20 0.54
NFKB1 P19838 1/20 0.54
BLM P54132 1/20 0.54
PMP22 Q01453 1/20 0.54
POLB P06746 2/20 0.54
PGR P06401 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29358626 1.00 CYP1A2 (1.00) CYP1A2MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL29695523 0.85 CYP1A2 (0.74) CYP1A2MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL763168 0.85 CYP1A2 (0.74) CYP1A2MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL6902600 0.82 RAB9A (0.72) CYP1A2MEN1KMT2ASMN1; SMN2ALDH1A1
Citric Acid SCHEMBL30368958 0.82 CYP1A2 (0.67) CYP1A2MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL29579885 0.81 CYP1A2 (0.69) CYP1A2MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL982104 0.81 CYP1A2 (0.69) CYP1A2MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL1838349 0.81 RAB9A (0.70) CYP1A2MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL30947438 0.81 LMNA (0.78) CYP1A2MEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL11049972 0.81 CYP1A2 (0.68) CYP1A2MEN1KMT2ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 354 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119789670-A Perovskite solar cell and preparation method thereof 中建科工集团有限公司 2025-04-08 CN claimed
EP-3606921-B1 NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA. INVENTIVA (FR) 2022-06-01 EP claimed
US-20170299609-A1 TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS WITH SK CHANNEL ACTIVATORS WRIGHT STATE UNIVERSITY (US) 2017-10-19 US claimed
EP-1513870-A4 CFTR MODIFIER GENES AND EXPRESSED POLYPEPTIDES USEFUL IN TREATING CYSTIC FIBROSIS AND METHODS AND PRODUCTS FOR DETECTING AND/OR IDENTIFYING SAME CHILDRENS HOSP MEDICAL CENTER (US) 2006-06-07 EP claimed
EP-1513870-A2 CFTR MODIFIER GENES AND EXPRESSED POLYPEPTIDES USEFUL IN TREATING CYSTIC FIBROSIS AND METHODS AND PRODUCTS FOR DETECTING AND/OR IDENTIFYING SAME Children's Hospital Medical Center (US) 2005-03-16 EP claimed
US-20040248099-A1 Use of intermediate -conductance potassium channels and modulators for diagnosing and treating diseases having disturbed keratinocyte activity SWITCH BIOTECH AKTIENGESELLSCHAFT (DE) 2004-12-09 US claimed
WO-2004039409-A2 COMPOSITION COMPRISING ACTIVATORS OF IK POTASSIUM CHANNELS AND CALCINEURIN ANTAGONISTS AND USE THEREOF SWITCH BIOTECH AG (DE) 2004-05-13 WO claimed
US-20040029773-A1 Use of 1-ebio in the treatment of bipolar disorders SMITHKLINE BEECHAM CORPORATION 2004-02-12 US claimed
WO-2003102140-A2 CFTR MODIFIER GENES AND EXPRESSED POLYPEPTIDES USEFUL IN TREATING CYSTIC FIBROSIS CHILDREN'S HOSPITAL MEDICAL CENTER (US) 2003-12-11 WO claimed
EP-1345618-A2 USE OF INTERMEDIATE-CONDUCTANCE POTASSIUM CHANNELS AND MODULATORS FOR THE DIAGNOSIS AND TREATMENT OF ILLNESSES HAVING DISTURBED KERATINOCYTE ACTIVITY Switch Biotech Aktiengesellschaft (DE) 2003-09-24 EP claimed
EP-1330247-A1 USE OF 1-EBIO IN THE TREATMENT OF BIPOLAR DISORDERS GLAXO GROUP LIMITED (GB) 2003-07-30 EP claimed
WO-2002053171-A2 USE OF INTERMEDIATE-CONDUCTANCE POTASSIUM CHANNELS AND MODULATORS FOR THE DIAGNOSIS AND TREATMENT OF ILLNESSES HAVING DISTURBED KERATINOCYTE ACTIVITY SWITCH BIOTECH AKTIENGESELLSCHAFT (DE) 2002-07-11 WO claimed
WO-2002036121-A1 USE OF 1-EBIO IN THE TREATMENT OF BIPOLAR DISORDERS GLAXO GROUP LIMITED (GB) 2002-05-10 WO claimed
US-6117223-A Hot melt inks containing polyketones XEROX CORPORATION (US) 2000-09-12 US claimed
US-6106599-A Inks XEROX CORPORATION (US) 2000-08-22 US claimed
US-12629356-B2 Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof IOVANCE BIOTHERAPEUTICS, INC. (US) 2026-05-19 US disclosed
EP-4695613-A2 METHODS OF MODIFYING NEURONS IN VIVO TO TREAT AND/OR PREVENT AMYOTROPHIC LATERAL SCLEROSIS (ALS) Yale University (US) 2026-02-18 EP disclosed
US-5053411-A Analgesics ANAQUEST, INC. (US) 1991-10-01 US disclosed
WO-1991001379-A1 METHOD OF TRANSCRIPTIONALLY MODULATING GENE EXPRESSION AND OF DISCOVERING CHEMICALS CAPABLE OF FUNCTIONING AS GENE EXPRESSION MODULATORS ONCOGENE SCIENCE, INC. (US) 1991-02-07 WO disclosed
EP-0396282-A2 N-aryl-N-[4-(heterocyclicalkyl) piperidinyl]amides and pharmaceutical compositions and methods employing such compounds BOC, INC. (US) 1990-11-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12629356-B2 Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof PBK, IL2, KCNN3 CYP1A2 2412/4885MEN1 3761/4885KMT2A 389/4885
US-20170299609-A1 TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS WITH SK CHANNEL ACTIVATORS KCNN3, KCNN2, KCNN1 CYP1A2 4841/4885MEN1 4559/4885KMT2A 1420/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.