Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15154238 | 1.00 | L3MBTL1 (0.48) | L3MBTL1KMT2ADPP4HPGDTSHR | |
| SCHEMBL15163834 | 0.84 | KMT2A (0.47) | L3MBTL1KMT2ADPP4SMN1; SMN2HTT | |
| SCHEMBL15154055 | 0.79 | HTT (0.48) | KMT2ASMN1; SMN2HTTALDH1A1LMNA | |
| SCHEMBL15154054 | 0.79 | HTT (0.48) | KMT2ASMN1; SMN2HTTALDH1A1LMNA | |
| SCHEMBL15154241 | 0.78 | L3MBTL1 (0.48) | L3MBTL1KMT2ADPP4HPGDTSHR | |
| SCHEMBL6128482 | 0.77 | L3MBTL1 (0.56) | L3MBTL1KMT2ADPP4HPGDTSHR | |
| SCHEMBL27001822 | 0.76 | SMN1; SMN2 (0.57) | L3MBTL1KMT2ADPP4HPGDTSHR | |
| SCHEMBL2525981 | 0.72 | ALDH1A1 (0.60) | L3MBTL1KMT2AHPGDTSHRSMN1; SMN2 | |
| SCHEMBL9141666 | 0.71 | ALDH1A1 (0.59) | L3MBTL1KMT2AHPGDTSHRSMN1; SMN2 | |
| SCHEMBL9141661 | 0.71 | ALDH1A1 (0.59) | L3MBTL1KMT2AHPGDTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130203735-A1 | CAPROLACTAM MGLUR5 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2013-08-08 | — | — | US | disclosed |
| US-20130203735-A1 | CAPROLACTAM MGLUR5 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2013-08-08 | — | — | US | disclosed |
| US-20130203735-A1 | CAPROLACTAM MGLUR5 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2013-08-08 | — | — | US | disclosed |
| WO-2012058128-A2 | CAPROLACTAM MGLUR5 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203735-A1 | CAPROLACTAM MGLUR5 RECEPTOR MODULATORS | GRM5, GRIK5, GRM1 | L3MBTL1 3530/4885KMT2A 2543/4885DPP4 1340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.