SCHEMBL6129157

SCHEMBL6129157

O=C=Nc1cccc2c1CCC(N=C=O)C2

nearest known ligand 0.39

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.39
DRD2 P14416 3/20 0.33
DRD3 P35462 3/20 0.33
CA1 P00915 2/20 0.32
CA2 P00918 2/20 0.32
ACHE P22303 2/20 0.32
MTNR1A P48039 1/20 0.32
MTNR1B P49286 1/20 0.32
CHRM2 P08172 1/20 0.31
CHRM1 P11229 1/20 0.31
CHRM3 P20309 1/20 0.31
ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4023875 0.76 PLAU (0.46) CA1CA2MTNR1AMTNR1BALDH1A1
SCHEMBL9710104 0.76 CYP3A4 (0.50) CYP3A4ALDH1A1
SCHEMBL1074719 0.73 CYP3A4 (0.47) CYP3A4ALDH1A1
SCHEMBL3630459 0.70 CYP3A4 (0.38) CYP3A4
SCHEMBL1193046 0.69 ANPEP (0.39) CA1CA2MTNR1AMTNR1BALDH1A1
SCHEMBL4021053 0.69 TRPA1 (0.33) ALDH1A1
SCHEMBL4016131 0.69 PSEN1 (0.35) ALDH1A1
SCHEMBL4015553 0.69 DRD2 (0.42) DRD2DRD3
SCHEMBL98142 0.68 CYP3A4 (0.39) CYP3A4
SCHEMBL7982007 0.66 MAOA (0.47) CYP3A4DRD2DRD3CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1506165-B1 TETRALIN ISOCYANATES BAYER MATERIALSCIENCE LLC (US) 2011-12-28 EP claimed
US-11795260-B2 Bulk material comprising solid diisocyanates and prepolymers containing urethane groups obtainable therefrom COVESTRO INTELLECTUAL PROPERTY GMBH & CO. KG (DE) 2023-10-24 US disclosed
US-20210163658-A1 BULK MATERIAL COMPRISING SOLID DIISOCYANATES AND PREPOLYMERS CONTAINING URETHANE GROUPS OBTAINABLE THEREFROM COVESTRO DEUTSCHLAND AG (DE) 2021-06-03 US disclosed
EP-3828213-A1 BULK MATERIAL CONTAINING SOLID DIISOCYANATES AND URETHANE GROUP-CONTAINING PREPOLYMERS OBTAINABLE THEREFROM Covestro Deutschland AG (DE) 2021-06-02 EP disclosed
EP-3828214-A1 BULK MATERIAL CONTAINING SOLID DIISOCYANATES AND URETHANE GROUP CONTAINING PREPOLYMERS PREPARED THEREFROM Covestro Intellectual Property GmbH & Co. KG (DE) 2021-06-02 EP disclosed
CN-112851904-A Bulk material comprising solid diisocyanate and urethane group-containing prepolymer obtainable therefrom 科思创知识产权两合公司 2021-05-28 CN disclosed
EP-1506165-B1 TETRALIN ISOCYANATES BAYER MATERIALSCIENCE LLC (US) 2011-12-28 EP disclosed
CN-1289473-C Tetralin isocyanates BAYER MATERIALSCIENCE LLC (US) 2006-12-13 CN disclosed
CN-1653041-A Tetralin isocyanates BAYER MATERIALSCIENCE LLC (US) 2005-08-10 CN disclosed
EP-1506165-A1 TETRALIN ISOCYANATES Bayer MaterialScience LLC (US) 2005-02-16 EP disclosed
US-6841585-B2 Tetralin isocyanates BAYER MATERIALSCIENCE LLC (US) 2005-01-11 US disclosed
US-20040143029-A1 Tetralin isocyanates COVESTRO LLC 2004-07-22 US disclosed
US-6750367-B2 REACTING 1,2,3,4-TETRAHYDRONAPHTHALENE WITH NITRIC ACID TO PRODUCE DINITROTETRALIN THEN HYDROGENATING TO DIAMINOTETRALIN AND PHOSGENATING BAYER POLYMERS LLC 2004-06-15 US disclosed
WO-2003095419-A1 TETRALIN ISOCYANATES BAYER MATERIALSCIENCE LLC (US) 2003-11-20 WO disclosed
US-20030212160-A1 Tetralin isocyanates COVESTRO LLC 2003-11-13 US disclosed