Bromide

Bromide

SCHEMBL6129306

Br.Oc1cccc2c1Cc1ccccc1O2

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.57
MAOB P27338 2/20 0.57
DRD2 P14416 2/20 0.44
DRD3 P35462 2/20 0.44
DRD1 P21728 1/20 0.44
DRD5 P21918 1/20 0.44
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA4 P22748 2/20 0.41
CA6 P23280 2/20 0.41
BCL2L1 Q07817 1/20 0.41
BAD Q92934 1/20 0.41
MAPKAPK2 P49137 2/20 0.41
GAA P10253 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
PTGS2 P35354 1/20 0.36
MEN1 O00255 1/20 0.36
USP2 O75604 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HPN P05981 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1980248 0.98 MAOA (0.59) MAOAMAOBDRD2DRD3DRD1
SCHEMBL7970202 0.80 MAOA (0.55) MAOAMAOBDRD2DRD3DRD1
SCHEMBL30346211 0.79 MAOA (0.53) MAOAMAOBCA1CA2CA4
SCHEMBL8649269 0.79 MAOA (0.53) MAOAMAOBCA1CA2CA4
SCHEMBL4809975 0.78 DRD2 (0.47) MAOAMAOBDRD2DRD3DRD1
SCHEMBL1979793 0.77 MAOA (0.52) MAOAMAOBCA1CA2CA4
Xanthene SCHEMBL30046640 0.77 MAOA (0.94) MAOAMAOBMAPKAPK2GAANPSR1
Xanthene SCHEMBL11600218 0.77 MAOA (0.94) MAOAMAOBMAPKAPK2GAANPSR1
Xanthene SCHEMBL2312744 0.77 MAOA (0.94) MAOAMAOBMAPKAPK2GAANPSR1
Xanthene SCHEMBL30047272 0.77 MAOA (0.94) MAOAMAOBMAPKAPK2GAANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1042727-A4 METHOD OF CANCER CELL DETECTION APPLIED SPECTRAL IMAGING LTD (IL) 2005-11-30 EP disclosed
EP-1015844-A4 SPECTRAL BIO-IMAGING METHODS FOR CELL CLASSIFICATION APPLIED SPECTRAL IMAGING LTD (IL) 2005-04-27 EP disclosed
US-6690817-B1 Spectral bio-imaging data for cell classification using internal reference APPLIED SPECTRAL IMAGING LTD. (IL) 2004-02-10 US disclosed
EP-1114393-A1 SPECTRAL BIO-IMAGING DATA FOR CELL CLASSIFICATION USING INTERNAL REFERENCE Applied Spectral Imaging Ltd. (IL) 2001-07-11 EP disclosed
EP-1042727-A1 METHOD OF CANCER CELL DETECTION Applied Spectral Imaging Ltd. (IL) 2000-10-11 EP disclosed
EP-1015844-A1 SPECTRAL BIO-IMAGING METHODS FOR CELL CLASSIFICATION Applied Spectral Imaging Ltd. (IL) 2000-07-05 EP disclosed
WO-2000017808-A1 SPECTRAL BIO-IMAGING DATA FOR CELL CLASSIFICATION USING INTERNAL REFERENCE APPLIED SPECTRAL IMAGING LTD. (IL) 2000-03-30 WO disclosed
US-5995645-A Method of cancer cell detection APPLIED SPECTRAL IMAGING LTD. (IL) 1999-11-30 US disclosed
US-5991028-A Spectral bio-imaging methods for cell classification APPLIED SPECTRAL IMAGING LTD. (IL) 1999-11-23 US disclosed
EP-0830564-A4 SPECTRAL BIO-IMAGING METHODS FOR BIOLOGICAL RESEARCH, MEDICAL DIAGNOSTICS AND THERAPY SPECTRAL DIAGNOSTIC LTD (IL) 1999-11-10 EP disclosed
WO-1999028856-A1 METHOD OF CANCER CELL DETECTION APPLIED SPECTRAL IMAGING LTD. (IL) 1999-06-10 WO disclosed
WO-1998043042-A9 SPECTRAL BIO-IMAGING METHODS FOR CELL CLASSIFICATION 1999-03-04 WO disclosed
WO-1998043042-A1 SPECTRAL BIO-IMAGING METHODS FOR CELL CLASSIFICATION APPLIED SPECTRAL IMAGING LTD. (IL) 1998-10-01 WO disclosed
US-5784162-A Spectral bio-imaging methods for biological research, medical diagnostics and therapy APPLIED SPECTRAL IMAGING LTD. (IL) 1998-07-21 US disclosed
EP-0830564-A1 SPECTRAL BIO-IMAGING METHODS FOR BIOLOGICAL RESEARCH, MEDICAL DIAGNOSTICS AND THERAPY Spectral Diagnostic Ltd (IL) 1998-03-25 EP disclosed
WO-1997021979-A1 SPECTRAL BIO-IMAGING METHODS FOR BIOLOGICAL RESEARCH, MEDICAL DIAGNOSTICS AND THERAPY SPECTRAL DIAGNOSTIC LTD. (IL) 1997-06-19 WO disclosed