Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | BAD | Q92934 | 1/20 | 0.41 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPN | P05981 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1980248 | 0.79 | MAOA (0.59) | DRD2DRD3DRD1DRD5BCL2L1 | |
| Bromide SCHEMBL6129306 | 0.78 | MAOA (0.57) | DRD2DRD3DRD1DRD5BCL2L1 | |
| SCHEMBL8468364 | 0.78 | MAOA (0.38) | HSD17B3MAOAMAOBALDH1A1KMT2A | |
| SCHEMBL7729132 | 0.77 | NPC1 (0.36) | DRD2DRD3DRD1DRD5HSD17B3 | |
| SCHEMBL7918691 | 0.76 | DRD2 (0.61) | DRD2DRD3DRD1DRD5BCL2L1 | |
| SCHEMBL31634362 | 0.76 | DRD2 (0.61) | DRD2DRD3DRD1DRD5BCL2L1 | |
| SCHEMBL7506305 | 0.74 | ALDH1A1 (0.36) | DRD2DRD3DRD1DRD5HSD17B3 | |
| SCHEMBL489968 | 0.73 | MAOA (0.61) | DRD2DRD3DRD1DRD5HSD17B3 | |
| SCHEMBL10585516 | 0.73 | AKR1B1 (0.42) | HSD17B3ALDH1A1PTGS1HSD17B10TDP1 | |
| SCHEMBL6907788 | 0.73 | DRD2 (0.52) | DRD2DRD3DRD1DRD5BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008070795-A2 | COMBINATION THERAPY USING LOW-DOSE DOXEPIN FOR THE IMPROVEMENT OF SLEEP | SOMAXON PHARMACEUTICALS, INC. (US) | 2008-06-12 | — | — | WO | disclosed |