Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GGT1 | P19440 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6129701 | 1.00 | PTGS2 (0.46) | PTGS2KDM4EALDH1A1ESR1ITGB3 | |
| SCHEMBL6129711 | 0.88 | PTGS2 (0.47) | PTGS2 | |
| SCHEMBL6129715 | 0.88 | PTGS2 (0.47) | PTGS2 | |
| SCHEMBL6129710 | 0.88 | PTGS2 (0.47) | PTGS2 | |
| SCHEMBL6129716 | 0.88 | PTGS2 (0.47) | PTGS2 | |
| SCHEMBL6129717 | 0.86 | PTGS2 (0.46) | PTGS2KDM4EHPGDTDP1 | |
| SCHEMBL6129719 | 0.86 | PTGS2 (0.46) | PTGS2KDM4EHPGDTDP1 | |
| SCHEMBL6129706 | 0.85 | TUBB4A (0.51) | PTGS2 | |
| SCHEMBL6129705 | 0.85 | TUBB4A (0.51) | PTGS2 | |
| SCHEMBL6129708 | 0.84 | PTGS2 (0.50) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1191929-A4 | (Z)-STYRYL ACETOXYPHENYL SULFIDES AS CYCLOOXYGENASE INHIBITORS | UNIV TEMPLE (US) | 2005-02-16 | — | — | EP | disclosed |
| US-6656968-B1 | Selectively inhibit the cyclooxygenase activity of COX-2 over COX-1; addition polymers of compound | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-12-02 | — | — | US | disclosed |
| EP-1191929-A2 | (Z)-STYRYL ACETOXYPHENYL SULFIDES AS CYCLOOXYGENASE INHIBITORS | Temple University of the Commonwealth System of Higher Education (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000077169-A2 | (Z)-STYRYL ACETOXYPHENYL SULFIDES AS CYCLOOXYGENASE INHIBITORS | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2000-12-21 | — | — | WO | disclosed |